NSC 185058|cas 39122-38-8

Cas No.:	39122-38-8
Chemical Name:	NSC 185058
Synonyms:	NSC 185058
SMILES:	S=C(C1=NC=CC=C1)NC2=NC=CC=C2
Formula:	C₁₁H₉N₃S
M.Wt:	215.3
Sotrage:	2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Description:	NSC 185058 is an ATG4B inhibitor. NSC185058 markedly attenuates autophagic activity[1].
In Vitro:	NSC185058 is an ATG4B antagonist. ATG4B stimulates autophagy by promoting autophagosome formation through reversible modification of ATG8. Inclusion of the ATG4B inhibitor NSC185058 enhances the anti-tumor activity of radiation therapy (RT). NSC185058 decreases glioblastoma (GBM) cell tumorigenicity, and enhances the anti-tumor activity of RT when applied to orthotopic GBM xenograft models[1].

Cat. No.	Product name	Field of application
DC11363	NSC 185058	NSC 185058 is an inhibitor of ATG4B, a cysteine protease that activates LC3B during the initiation of autophagy.
DC8730	Cambendazol	Cambendazol is an antihelmintic that, at a dose of 50 mg/kg/day in mice, eradicates S. ratti adult worms from intestine and S. stercoralis larva from muscle.